Please ensure Javascript is enabled for purposes of website accessibility

Call us now on 0238 2000 200

ReferralAppointments
All Treatments

Wet AMD

Wet macular degeneration causes fluid and haemorrhages on the macula which result in a sudden drop in the vision of the affected eye. It is very important to treat wet macular degeneration early to give the best chance of stabilising or improving the eye sight. Treatment involves repeated injections of antiVEGF (vascular endothelial growth factor) into the eye. The response to injections is monitored at regular intervals.

Most age-related macular degeneration (AMD) patients start with the dry form. Ten per cent of these people will go on to develop the wet form of the disease. Although the wet type is much less common, it tends to be more aggressive, causing greater and more rapid visual loss.

In response to retinal degeneration, new blood vessels from the choroid (the deeper vascular layer of the eye) sometimes develop beneath the retina, like weeds growing up through the cracks in a pavement.

This process is called neovascularisation. Neovascularisation does not help the retina because the vessels are very fragile and easily leak or bleed. Eventually, this process results in the formation of a disc-shaped grey scar in the middle of the visual field. The scar may take some time to form, but once established, all retinal tissue in the area is destroyed, leaving a large central blind spot. Macular degeneration cannot be reversed once this has occurred.

Definition

What Is Wet AMD?

Causes

Causes Of Wet AMD

Symptoms

Symptoms Of Wet AMD

Treatments

Treatments For Wet AMD

Although the wet form of AMD tends to be more aggressive than the dry form, it is amenable to certain types of treatment. We can help you to decide which treatment might be most appropriate for you.

Anti-VEGF injection treatments for wet AMD

What are anti-VEGF injection treatments?
How do antiVEGF injections work?
Are anti-VEGF injections a proven treatment for wet AMD?

What are anti-VEGF injection treatments?

Anti-VEGF injections into the eye are the most recent and most successful treatment for wet age-related macular degeneration (AMD). Anti-VEGF injections work by blocking a protein called VEGF (vascular endothelial growth factor), which stimulates formation of new blood vessels. This means that the anti-VEGF injections inhibit the growth of new abnormal blood vessels in your eye.

Anti-VEGF injection treatments can help to slow the visual loss, and in some cases may even improve sight. The antiVEGF treatments in current use are Eylea, Lucentis, Vabysmo, Beovu and Avastin.

How do antiVEGF injections work?

Lucentis is an anti-VEGF injection treatment for the management of wet AMD. It acts as an antibody, both preventing the growth of abnormal blood vessels beneath the retina and stopping fluid from leaking. This can protect the central macular area of the retina from permanent damage. In formal clinical trials, Lucentis produced good results. It has been approved for use by regulatory bodies in the United States, Europe and the United Kingdom, since 20 years ago.

Avastin is an alternative antibody treatment for wet age-related macular degeneration. It was actually developed to treat colorectal and lung cancer, and has never had formal ophthalmic evaluation. However, a number of studies have shown it to be equally effective with Lucentis, and in the United States this is now the most common injection choice.

Eylea works in a slightly different way to Lucentis and Avastin, by trapping VEGF and protecting the macula from its damaging effects. There have been extensive trials of the drug, and one potential advantage of Eylea is that it may require fewer injections. Eylea is now available in a longer interval preparation of 8mg per dose.

Vabysmo (Faricimab) was licensed for the treatment of wet AMD recently (2020). Its mode of action is similar to Lucentis but also blocks ang-2 receptors on blood vessels thereby preventing abnormal growth. Vabysmo injections are given at longer intervals than Lucentis or Avastin.

Beovu (Brolucizumab) was licensed for use about 5 years ago. It showed promise as a drug that could be given at longer intervals, however there were concerns from some about the higher incidence of uveitis (inflammation).

Are anti-VEGF injections a proven treatment for wet AMD?

Extensive clinical testing on Lucentis and Eylea has established the effectiveness of anti-VEGF injections as an exciting and effective treatment for wet AMD. The newer drugs such as Eylea 8mg, Vabysmo and Beovu are supported by very good clinical trials and level I studies.

Although there has been no clinical trial of Avastin in wet AMD, there are now many research reports and papers supporting its use. Avastin is closely related to Lucentis, which has produced spectacular results in formal clinical trials, and has been approved by the National Institute for Health and Clinical Excellence (NICE) for routine use.

What are anti-VEGF injection treatments?

Anti-VEGF injections into the eye are the most recent and most successful treatment for wet age-related macular degeneration (AMD). Anti-VEGF injections work by blocking a protein called VEGF (vascular endothelial growth factor), which stimulates formation of new blood vessels. This means that the anti-VEGF injections inhibit the growth of new abnormal blood vessels in your eye.

Anti-VEGF injection treatments can help to slow the visual loss, and in some cases may even improve sight. The antiVEGF treatments in current use are Eylea, Lucentis, Vabysmo, Beovu and Avastin.

How do antiVEGF injections work?

Lucentis is an anti-VEGF injection treatment for the management of wet AMD. It acts as an antibody, both preventing the growth of abnormal blood vessels beneath the retina and stopping fluid from leaking. This can protect the central macular area of the retina from permanent damage. In formal clinical trials, Lucentis produced good results. It has been approved for use by regulatory bodies in the United States, Europe and the United Kingdom, since 20 years ago.

Avastin is an alternative antibody treatment for wet age-related macular degeneration. It was actually developed to treat colorectal and lung cancer, and has never had formal ophthalmic evaluation. However, a number of studies have shown it to be equally effective with Lucentis, and in the United States this is now the most common injection choice.

Eylea works in a slightly different way to Lucentis and Avastin, by trapping VEGF and protecting the macula from its damaging effects. There have been extensive trials of the drug, and one potential advantage of Eylea is that it may require fewer injections. Eylea is now available in a longer interval preparation of 8mg per dose.

Vabysmo (Faricimab) was licensed for the treatment of wet AMD recently (2020). Its mode of action is similar to Lucentis but also blocks ang-2 receptors on blood vessels thereby preventing abnormal growth. Vabysmo injections are given at longer intervals than Lucentis or Avastin.

Beovu (Brolucizumab) was licensed for use about 5 years ago. It showed promise as a drug that could be given at longer intervals, however there were concerns from some about the higher incidence of uveitis (inflammation).

Are anti-VEGF injections a proven treatment for wet AMD?

Extensive clinical testing on Lucentis and Eylea has established the effectiveness of anti-VEGF injections as an exciting and effective treatment for wet AMD. The newer drugs such as Eylea 8mg, Vabysmo and Beovu are supported by very good clinical trials and level I studies.

Although there has been no clinical trial of Avastin in wet AMD, there are now many research reports and papers supporting its use. Avastin is closely related to Lucentis, which has produced spectacular results in formal clinical trials, and has been approved by the National Institute for Health and Clinical Excellence (NICE) for routine use.

Frequently asked questions

What is wet macular degeneration and how does Anti-VEGF therapy work?

Wet macular degeneration is an advanced form of age-related macular degeneration (AMD) where abnormal blood vessels grow beneath the retina and leak fluid or blood, disrupting the macula’s normal function and architecture, which can rapidly damage and scar the macula leading to central vision loss. Anti-VEGF therapy targets the protein responsible for the pathological blood vessel growth, helping to slow the progression of the disease and in some cases, even improve vision.

How effective is Anti-VEGF therapy in treating wet macular degeneration?

Anti-VEGF therapy has been a game-changer in the treatment of wet AMD, with the majority of patients at Sapphire Eye Care experiencing a cessation of disease progression. While individual results can vary, many patients also see an improvement in their vision, especially when treatment is initiated promptly after the onset of symptoms.

Are there side effects associated with Anti-VEGF injections?

As with any medical procedure, there are potential side effects associated with Anti-VEGF injections, though they are generally well-tolerated. Patients may experience some discomfort, redness, or temporary visual disturbances. The risk of more serious side effects, such as infection or retinal detachment, is low but underscores the importance of receiving treatment in a specialist clinic like Sapphire Eye Care.

How long do patients need to receive Anti-VEGF treatments?

The treatment regimen for wet AMD at Sapphire Eye Care is highly individualised. Some patients may respond well to initial treatments and require less frequent maintenance injections, while others may need ongoing, regular injections to control their condition. Our specialists work closely with each patient to determine the most effective and sustainable treatment frequency.

What can patients expect from Anti-VEGF treatments at Sapphire Eye Care?

Patients undergoing Anti-VEGF treatments at Sapphire Eye Care can expect a personalised treatment plan that typically involves a series of injections directly into the eye after the application of local anaesthesia. The procedure is performed in a controlled environment and is relatively quick. While some patients may notice an improvement in their symptoms shortly after the treatment, others may require ongoing injections to maintain their vision.